New Research Finds That With Obesity, the Problem Isn’t an Excess of Fat but Its Loss of Function
CELL PRESS • May 23, 2024
Obesity is known to cause cardiometabolic diseases like hypertension and diabetes but attributing these diseases to merely an overabundance of fat is a simplification. On a basic level, fat acts as a receptacle to store energy, but upon a closer look it is an essential actor in vital bodily processes like the immune response, the regulation of insulin sensitivity, and maintenance of body temperature. In a review published in the journal Cell on February 3rd, 2022, researchers argue that the negative health effects of obesity stem not simply from an excess of fat but from the decline in its ability to respond to changes, or in other words, its plasticity.
The makeup and functioning of this tissue changes in response to weight fluctuations and aging. As fat declines in plasticity due to aging and obesity, it loses its ability to respond to bodily cues. In the current model of this phenomenon, the rapid growth of adipose tissue outpaces its blood supply, depriving the fat cells of oxygen and causing the accumulation of cells that no longer divide. This leads to insulin resistance, inflammation, and cell death accompanied by the uncontrolled spill of lipids from these cells.
The hallmarks of adipose tissue dysfunction. Credit: Sakers et al./Cel
“The central role of adipose tissue dysfunction in disease and the incredible plasticity of fat tissue supports the promise of modulating fat tissue phenotypes for therapeutic purposes,” write the authors, led by Claudio J. Villanueva from the College of Life Sciences/David Geffen School of Medicine and Patrick Seale from Perelman School of Medicine at the University of Pennsylvania. “Many questions and opportunities for future discovery remain, which will yield new insights into adipose tissue biology and hopefully lead to improved therapies for human disease.”
Reference: “Adipose tissue plasticity in health and disease” by Alexander Sakers, Mirian Krystel De Siqueira, Patrick Seale and Claudio J. Villanueva, 3 February 2022, Cell.
DOI: 10.1016/j.cell.2021.12.016
Research reported in this publication was supported by NIDDK at the National Institutes of Health, the UCLA Life Sciences Fund, and UCLA Graduate Council Diversity Fellowship. The authors declare no competing interests.
Originally posted on January 30,2023, this article has been updated on August 24, 2024 to reflect the latest research and statistics. Our editorial team has ensured you’re viewing the most current data on this topic. Need help or have a question? Email us.
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At the very least, you'll want to keep this to a minimum. Inflammation is often visible—think red skin or a swollen knee. However, inflammation can also occur on the inside, and it's not always so easy to detect. "Inflammation is a physiological process involved in the defense of our body and the repair of tissues," says Jenna Stangland, RD , a Momentous advisor. Stangland explains that inflammation can be triggered by infections, trauma, toxins or allergic reactions. Sometimes, it becomes chronic in the muscles and tissues. Unfortunately, Stangland says chronic inflammation carries risks. "Chronic inflammation can end up stimulating the development of cardiovascular diseases, autoimmune disease, neurological disease or cancer," Stangland says. "This type of inflammation can last several months as a result of inability to combat and reduce it." Diet isn't a cure-all for chronic inflammation or the diseases it can trigger. However, it's an important tool. "Diet plays a significant role in inflammation, as certain foods can either promote or reduce inflammation in the body," says Michelle Routhenstein, MS, RD, CDCES, CDN , a preventive cardiology dietitian at EntirelyNourished.com . One food in particular is worth avoiding. RDs shared the food to limit if you have chronic inflammation. Related: The One Diet That Will Actually Lower Your Heart Attack Risk, According to Cardiologists
What does the medical peer reviewed literature say may be at the root of the following diseases: Metabolic Syndrome/Insulin Resistance/Diabetes Cardiovascular Disease Cancer Obesity Depression Autoimmune Disease Neurodegenerative disease (Alzheimer's and Parkinson's disease) Osteoporosis Immunosenescence (the progressive decline in immune function with increasing age) The Answer is: INFLAMMATION
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